Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases. One pathway that has received much attention in this context is transforming growth factor‐beta (TGF‐β) signalling, particularly during the regulation of epithelial‐mesenchymal transition (EMT) and tumour progression. While E3‐ubiquitin ligases offer themselves as potential therapeutic targets, much remains to be unveiled regarding mechanisms that culminate in their (...) regulation. With this in mind, the focus of this review highlights the regulation of the ubiquitination pathway and the significance of a recently described group of NEDD4 E3‐ubiquitin ligase isoforms in the context of TGF‐β pathway regulation. Moreover, we now broaden these observations to incorporate a growing number of protein isoforms within the ubiquitin ligase superfamily as a whole, and discuss their relevance in defining a new ‘iso‐ubiquitinome’. (shrink)

This book examines all verses of the Quran involving knowledge related concepts. It begins with the argument that an analysis of the Quranic concept of ignorance points to epistemic virtues that can pave our way towards gaining knowledge and/or understanding. It deals with the Quranic concepts of perceptual, rational, and revelatory knowledge as well as understanding and wisdom in the light of recent discussions in Western analytic epistemology. It also argues that the relevant Quranic verses seem to involve concept of (...) an epistemic conscience whose proper exercise can yield knowledge or understanding. While not overlooking the Quranic emphasis on revelation as a source of knowledge, the book draws our attention to a remarkable overlap between some strains of contemporary virtue epistemology and Quranic approach to knowledge. It shows that the Quranic verses suggest a progressive sequence from propositional knowledge to understanding to wisdom. (shrink)

The European Legacy, Volume 17, Issue 3, Page 414-415, June 2012.

Tarekat teaches its followers not to glorify conglomerates, to keep their distance from leader, and to live in a way of zuhud, including in the matters of politics. But the Tarekat Qadiriyah wa Naqsyabandiyah in Cukir Jombang was actually involved in practical politics as a supporter of Partai Persatuan Pembangunan. This paper, which was written in the form of ethnographic design according to the concept of the power relations of Foucault to find new perspectives about the actions of Tarekat communities (...) in politics, in this case explaining the pattern of relations that occurred between the Tarekat Cukir and PPP and discovering the factors causing Tarekat Cukir to support PPP. This paper concludes that between Tarekat Cukir and PPP, there is a mutually beneficial pattern of relations in terms of proximity, but in terms of economic politics, the Tarekat Cukir feels disadvantaged. The dominant reason the Tarekat Cukir supports PPP is because of the dependence of Santri on their Mursyid who is a PPP politician. This is reinforced by the history between the two parties and the spiritual ties that connect the teachers who are both PPP politicians and Santris. (shrink)

The restoration of "forgotten" names to the bosom of our culture is a natural and necessary accompaniment of the political freedom beginning to make its way in our country. Free and continuous creativity is being reunited with the reader, the listener, and the participant, who had been tragically alienated from it. Our half-knowledge, intellectual arbitrariness, and opportunism are becoming clearer, more acute, and more shameful. All this is an inevitable accompaniment of one of the most prestigious and, it would seem, (...) least labor consuming trends in contemporary publishing and journal policy. The publication of texts of Russian philosophers has marked journals as different in character and mission as Novyi mir, Voprosy filosofii, Literaturnaia ucheba, Druzhba narodov, Volga, and many others. In most cases they are more or less well known works reprinted from the YMCA Press, equipped with prefaces—some better, some worse—and devoid of any sort of real intellectual commentary. (shrink)

The article analyzes the dignity of a person in secular and Orthodox aspects. The authors argue that every phenomenon of the material and spiritual world is objectively inherent in internal contradictions, so it is not an exception and an idea of human dignity in secular and religious contexts. The research methods are comprehensive and based on the philosophical, anthropological and philosophical and cultural analysis of human dignity in secular and Orthodox dimensions. Discussion. The concepts of «secular» (universal) and «Christian» morality (...) are characterized and distinguished. The authors argue that the latter comes from a supernatural source, from a moral law, the basis of which is the belief in the immortality of the human spirit. Christian morality provides such norms of behavior of people in which the biblical moral commandments are observed.The roots of the universal morality are in a culture that has produced a humanistic outlook, within which a person is recognized as self -sufficient value, capable of asserting his dignity, transforming himself and the world without the intervention of a transcendental super -sensory nature (God). The universal morality is the principles and norms that regulate the behavior of people, the activities of their communities, associations in terms of universally recognized ideas about good and evil, honesty and disobedience, honesty and dishonesty. Finally, the article suggests that, despite the differences, and sometimes contradictions in the understanding of the essential manifestations of human dignity between secular and Christian contexts, quite obvious to both aspects is the understanding that the leading place should be occupied by the personality that manifests itself manifestation and individual aspiration, in the depths of its own consciousness and in its desire for free self -determination and creativity, as a prerequisite for the affirmation of one’s dignity. (shrink)

Human opacity is the intrinsic quality of unknowabil- ity of human beings with respect to machines. The descriptive rela- tionship between humans and machines, which captures how much information one can gather about the other, can be explicated using an opacity-transparency relationship. This relationship allows us to describe and normatively evaluate a spectrum of opacity where humans and machines may be either opaque or transparent. In this paper, we argue that the advent of Affective Computing (AC) has begun to shift (...) the ideal position of humans on this spectrum towards greater transparency, while much of this technology is shifting towards opacity. We explore the implications of this shift with regard to the affective information of humans and how the threat to human opacity by AC systems has various adverse repercussions, such as infringement of one’s autonomy, deception, manipulation, and increased anxiety. There are also distributive consequences that expose vulnerable groups to unjustified burdens and reduce them to mere profiles. We further provide an assessment of current AC technology, which follows the descriptive relationship between humans and machines from the lens of opacity and transparency. Finally, we foresee and address three possible objections to our claims. These are the beneficence of AC systems, their relation to privacy, and their restrictive capacity to capture human affects. Through these arguments, the paper aims to bring attention to the ontological relationship between humans and machines from the perspective of opacity and transparency while emphasizing on the gravity of the ethical concerns raised by their threat to human opacity. (shrink)